Mattel Children's Hospital at UCLA

Pertussis Study - Objective and Study Design
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Objective:  
The overall purpose of this multicenter prospective cohort study is to describe the societal burden of severe pertussis in the US pediatric population from clinical and health outcome perspectives.
Children < 18 years of age with pertussis who require hospitalization in the pediatric intensive care unit (PICU) during their illness will be studied (critical pertussis).

The specific aims of this study are:
Specific Aim 1. Characterize children’s presentation and acute course of critical pertussis during the PICU admission. Assess severity of illness (Pediatric Risk of Mortality (PRISM III)) at the time of PICU admission, provision of selected modalities of therapy, lengths of ventilatory support, duration of PICU stay, and disposition, including neurologic status, at the time of discharge.

Specific Aim 2. Assess reported health status and family impact in children following discharge from the PICU.

Specific Aim 3. Assess developmental sequelae and quality of life 12 months after discharge from the PICU, for infants who were admitted to the PICU at < 12 months of gestational age, using standardized tools.

Specific Aim 4. Assess risk factors associated with developmental sequelae in children who were admitted to the PICU at < 12 months of gestational age.

Eligibility:  
Eligible subjects for this study are those who meet one of the enrollment case definitions for pertussis:
- Childen < 18 years of age, and require hospitalization in a pediatric intensive care unit (PICU) during their pertussis illness.
Subjects must have:
Spent > or = 24 consecutive hours in PICU; OR
Spent any time in the PICU and died in the unit

Please review case definitions in the protocol