Regulatory
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Another unique aspect of having to conduct studies at two sites is our requirement to interact with two independent Investigational Review Boards, the Committee on Clinical Investigation (CCI) for CHLA and the Office for the Protection of Research Subjects (OPRS) for UCLA. In 2006 we submitted each CPCCRN study to the IRB independently.
However, as more studies are being conducted within the network, we have started “cross” submissions between the two Investigational Review Boards. In doing this we hpoed to conduct research activities between the two universities interchangeably.

CHLA IRB

Named as - “Committee on Clinical Investigations” (“CCI”)
Located at the Saban Research Institute
The Committee on Clinical Investigations (CCI) is the Institutional Review Board (IRB) of Children's Hospital Los Angeles.
It is charged with protecting the rights and welfare of human research subjects in research studies conducted at CHLA and elsewhere by CHLA faculty or staff, using CHLA patients or private information about CHLA patients, and funded by or through CHLA.

The CCI comprises members from a variety of scientific disciplines as well as community and lay members to assure a comprehensive review process.

Electronic Submission


UCLA IRB

Named as - The Office for Protection of Research Subjects (OPRS)

Located at the Ueberroth Building
Five IRBs at the UCLA Campus – MIRB 1 to 5
Serves as the administrative arm for federally mandated compliance committees responsible for reviewing all research protocols that involve the use of human and animal subjects.
Charged with implementing University policies that are based on federal regulations and State laws, the committees are composed of faculty, community representatives and consultants representing special subject populations.

Paper Based Submission