Children's Hospital of Los Angeles - Therapeutic Hypothermia After Pediatric
Cardiac Arrest (THAPCA) Trials
Hypothesis, Study Design, Inclusion and Exclusion Criteria
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Research Hypotheses for the THAPCA Trial:
Therapeutic Hypothermia (TH) will improve survival and neurobehavioral outcome
following out-of-hospital CA in children (THAPCA-OH Trial) (similar to adult OH
RCTs); and TH will improve survival and neurobehavioral outcome following
in-hospital CA in children (THAPCA-IH Trial)
Safety hypothesis for THAPCA Trials: TH will not increase (a) all-cause 28 day
mortality, (b) incidence of infections, (c) arrhythmias, and (d) blood product
administration within 7 days of CA in either in-hospital or out-of-hospital
cohorts
Study Design:
Conceptually simple RCT(s) proposed; One intervention (Hypothermia vs Control);
Two treatment strata (Out-of-hospital; In-hospital)
Link to the
Inclusion and Exclusion Criteria